CCN1/Cyr61 associates with β-amyloid levels in human cerebrospinal fluids
Mitsuru Shinohara, Hiroyuki Momota, Tsuyoshi Saito, Chisako Takenobu, Kensaku Kasuga, Ghupurjan Gheni, Kaori Kawai, Maho Morishima, Yuko Saito, Akihiro Shindo, Fumihiko Yasuno, Takeshi Ikeuchi, Akio Fukumori, Naoyuki Sato · 2026
Read CCN1/Cyr61 associates with β-amyloid levels in human cerebrospinal fluids by Mitsuru Shinohara, Hiroyuki Momota, Tsuyoshi Saito, Chisako Takenobu, Kensaku Kasuga, Ghupurjan Gheni, Kaori Kawai, Maho Morishima, Yuko Saito, Akihiro Shindo, Fumihiko Yasuno, Takeshi Ikeuchi, Akio Fukumori, Naoyuki Sato (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13265892.txt.
Description
Mitsuru Shinohara and colleagues relate a secreted protein called CCN1 to Alzheimer markers in spinal fluid, in a 2026 study. CCN1 is raised in Alzheimer brains and tied to cell ageing. Its levels in spinal fluid were unclear. A sensitive test measured samples from 79 people who had a spinal tap.
CCN1 tracked strongly with amyloid measures and with phosphorylated tau. Links with the amyloid ratio were also clear. Associations with glial and vessel markers were only moderate. Those other markers linked far more weakly to amyloid and tau. The authors see CCN1 as a clue connecting ageing biology with Alzheimer pathology.
Catalog record
| CREATOR | Mitsuru Shinohara, Hiroyuki Momota, Tsuyoshi Saito, Chisako Takenobu, Kensaku Kasuga, Ghupurjan Gheni, Kaori Kawai, Maho Morishima, Yuko Saito, Akihiro Shindo, Fumihiko Yasuno, Takeshi Ikeuchi, Akio Fukumori, Naoyuki Sato |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |