DAT-SPECT-based subtype and stage inference in Parkinson’s disease
Masakazu Ozawa, Daisuke Yoshimaru, Ami Yuzawa, Kenji Ishii, Hirotaka James Okano · 2026
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Description
Parkinson's disease wears away the brain's dopamine system, but the pattern of loss differs from patient to patient. Masakazu Ozawa and four co-authors used brain scans to sort those patterns in a 2026 study. They analyzed a scan type that images the dopamine transporter in 636 patients who had not yet taken Parkinson's drugs, plus 126 healthy controls.
A method that infers subtype and stage from the data found three steady patterns of loss. Two began at the back of the putamen, on the left or the right side. The third centered on both caudate regions, and its patients were older with heavier thinking and mood burdens. Over four years of follow-up, the patterns stayed stable. Motor gains from treatment were stronger in the first two groups, while mood and impulse problems grew in different groups.
Catalog record
| CREATOR | Masakazu Ozawa, Daisuke Yoshimaru, Ami Yuzawa, Kenji Ishii, Hirotaka James Okano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |