Hypoxia-driven transcriptional activation of MIR100HG by HIF-1α contributes to adaptive gene regulation in hepatocellular carcinoma
Nelin Hacioglu, Aylin Turkoglu Dulger, Sevin Avsar Koc, Esra Tokay, Meltem Alper, Feray Kockar · 2026
Read Hypoxia-driven transcriptional activation of MIR100HG by HIF-1α contributes to adaptive gene regulation in hepatocellular carcinoma by Nelin Hacioglu, Aylin Turkoglu Dulger, Sevin Avsar Koc, Esra Tokay, Meltem Alper, Feray Kockar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13265603.txt.
Description
Nelin Hacioglu and colleagues published a 2026 study on a long non-coding RNA, a gene-like stretch that does not build proteins, in liver cancer, which grows in low-oxygen conditions. The RNA, MIR100HG, responds to oxygen lack, but its control was unclear. The team tested four liver cancer cell lines and a normal liver cell line.
MIR100HG was highest in one cancer line and rose under low oxygen in all models. Low oxygen itself slowed growth, movement, and colony forming, most strongly in normal cells. Gene-switch tests proved the oxygen sensor HIF-1 alpha directly turns MIR100HG on, through sites in its promoter region. RNA profiling tied MIR100HG to a selected set of oxygen-response genes and pathways from stress to iron-driven cell death. The authors propose it as a marker and treatment target.
Catalog record
| CREATOR | Nelin Hacioglu, Aylin Turkoglu Dulger, Sevin Avsar Koc, Esra Tokay, Meltem Alper, Feray Kockar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69585 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |