TRIM37 interacts with PTEN to promote progression of hepatocellular carcinoma cells by modulating AKT/GSK-3β/β-Catenin pathway
Qingqing Wang, Xiaojian Zhang, Jie Zhang · 2026
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Description
Qingqing Wang, Xiaojian Zhang, and Jie Zhang study a protein called TRIM37 in liver cancer cells, in a 2026 laboratory investigation. TRIM37 tags other proteins for disposal and is implicated in many cancers. Its precise role in liver cancer was insufficiently understood. Two liver cancer cell lines were engineered to raise or lower it.
TRIM37 was overexpressed in tumour tissues and cell lines. Raising it boosted cell growth and invasion. Mechanistic tests showed it tagged a protective protein, PTEN, for destruction. Losing PTEN switched on a growth pathway involving AKT and beta-catenin. The authors propose blocking this chain as a treatment approach.
Catalog record
| CREATOR | Qingqing Wang, Xiaojian Zhang, Jie Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |