Prognostic significance and pathological correlation analysis of DKK4 in colorectal cancer
Xiaoxiong Wang, Minghai Shan, Xia Qiao, Lu Ding, Jiali Yang, Fang He, Yushen Mian, Xu Zhang, Shaoqi Yang · 2026
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Description
Xiaoxiong Wang and colleagues examine a protein called DKK4 across colorectal growths, in a 2026 study. Colorectal cancer develops stepwise from normal lining through benign adenomas. Markers for early precancerous stages are scarce. Tissue staining and data analysis tracked DKK4 at each stage.
DKK4 was low in normal tissue, rose in adenomas, and peaked in high-grade precancerous lesions. Levels then fell notably in invasive cancer. Expression linked to mutation burden and to a growth pathway called Wnt. A risk model built with DKK4 showed modest predictive accuracy. The pattern may help flag lesions needing closer attention.
Catalog record
| CREATOR | Xiaoxiong Wang, Minghai Shan, Xia Qiao, Lu Ding, Jiali Yang, Fang He, Yushen Mian, Xu Zhang, Shaoqi Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |