Micropeptide colorectal neoplasia differentially expressed (CRNDE) 84aa encoded by CRNDE elicits a T-cell immune response to breast cancer
Lili Zeng, Peng Hu, Changsong Bai, Yujia Luo, Xinyu Fang, Xinyu Liu, Qingyi Yuan, Xiaofeng Zhu · 2026
Read Micropeptide colorectal neoplasia differentially expressed (CRNDE) 84aa encoded by CRNDE elicits a T-cell immune response to breast cancer by Lili Zeng, Peng Hu, Changsong Bai, Yujia Luo, Xinyu Fang, Xinyu Liu, Qingyi Yuan, Xiaofeng Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13265216.txt.
Description
Lili Zeng and colleagues show that a hidden peptide from a non-coding RNA can trigger immune attack on breast cancer, in a 2026 study. Tumour antigens that wake immunity are central to immunotherapy. Non-coding RNAs can secretly encode small peptides. One such RNA, CRNDE, is raised in breast tumours.
Laboratory tests confirmed production of its 84-amino-acid peptide. A predicted fragment of the peptide provoked a specific T-cell response. Killer T cells from a patient recognised and destroyed matching cancer cells. In mouse models with patient tumours, enriched T cells protected against tumour challenge. The peptide emerges as a candidate vaccine antigen.
Catalog record
| CREATOR | Lili Zeng, Peng Hu, Changsong Bai, Yujia Luo, Xinyu Fang, Xinyu Liu, Qingyi Yuan, Xiaofeng Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |