The anti-migratory effect of curcumin in colorectal cancer involves IKKβ/NF-κB/Snail-mediated EMT inhibition
Bei Liu, Lu Xiao, Jing Shi, Jun Zhang, Min Chen · 2026
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Description
Bei Liu and colleagues test curcumin, a plant compound, against colorectal cancer cell movement, in a 2026 laboratory study. Spread to distant organs causes most deaths from this cancer. A process called epithelial-mesenchymal transition helps cells move and invade. A signalling chain involving IKKβ, NF-κB, and Snail drives that process.
Two cancer cell lines were exposed to curcumin for two days. The compound stalled the cell cycle and cut growth, colony formation, and migration in a dose-related way. A marker of stable cell identity rose, while movement-related proteins fell. The results suggest curcumin restrains movement by quieting that signalling chain, a lead for further testing.
Catalog record
| CREATOR | Bei Liu, Lu Xiao, Jing Shi, Jun Zhang, Min Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |