LncRNA SOX21-AS1 is associated with poor prognosis and immunomodulation in glioblastoma
Yanyan Yang, Jiayao Sun, Yan Fang, Wei Shan, Pengfei Li, Yaxuan Ma, Weimin Ni · 2026
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Description
Yanyan Yang and colleagues build a survival model for glioblastoma from long non-coding RNAs, in a 2026 study. Glioblastoma is the most malignant brain tumour type, with poor outlook. Long non-coding RNAs do not build proteins, yet they can steer cell behaviour. Their joint value for prognosis was the focus here.
A model using nineteen such RNAs split patients into high-risk and low-risk groups. Survival differed sharply between groups, and accuracy was high. High-risk tumours showed distinct immune cell mixes and checkpoint patterns. Five hub RNAs were highlighted, including SOX21-AS1. That RNA linked with a key immune signal and with better outlook, suggesting a protective role.
Catalog record
| CREATOR | Yanyan Yang, Jiayao Sun, Yan Fang, Wei Shan, Pengfei Li, Yaxuan Ma, Weimin Ni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |