Comprehensive genomics and functional analyses identify SMARCAL1 as a key oncogenic regulator in lung adenocarcinoma
Zehao Huang, Yue Li, Jundao He, Zhanyu Xu, Huajian Peng, Nuo Yang · 2026
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Description
Zehao Huang and colleagues identify a DNA-maintenance gene called SMARCAL1 as a driver in lung adenocarcinoma, in a 2026 study. The gene helps keep the genome stable, and its disruption may fuel tumours. Its value as a marker for this lung cancer was untested. Public tumour data and laboratory experiments were combined.
SMARCAL1 levels were higher in lung adenocarcinoma and rose with tumour stage. Lowering the gene in cancer cells slowed growth, movement, and invasion. A prediction model built with its levels forecast survival well. High levels also linked to higher mutation counts and weaker anti-tumour immunity. The authors propose SMARCAL1 as a marker and possible target.
Catalog record
| CREATOR | Zehao Huang, Yue Li, Jundao He, Zhanyu Xu, Huajian Peng, Nuo Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |