Hepatogenomics of MAFLD in Asian Population: Genetic Polymorphisms and Pathway-Based Insights
Matthew Justyn, Cheerly Sutanto, Melisa Intan Barliana, Henhen Heryaman, Anna Meiliana, Irma Melyani Puspitasari · 2026
Read Hepatogenomics of MAFLD in Asian Population: Genetic Polymorphisms and Pathway-Based Insights by Matthew Justyn, Cheerly Sutanto, Melisa Intan Barliana, Henhen Heryaman, Anna Meiliana, Irma Melyani Puspitasari (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13265007.txt.
Description
Matthew Justyn and colleagues published a 2026 review of the genetics of fatty liver disease tied to metabolic dysfunction in Asian populations. The disease is rising fast in Asia, strikes younger people, and varies greatly between patients. Genes help explain who stores liver fat, who progresses to liver inflammation, and who scars.
The review groups variants by pathway: fat handling, insulin resistance and new fat making, cholesterol handling, inflammation, and scarring. One variant in the PNPLA3 gene stood out as the strongest driver of liver fat and harsh tissue features across studies. Other variants raised or lowered risk. Frequencies and effect sizes differ between Asian and Western groups. The authors back adding genetic markers to risk models so high-risk people are found earlier.
Catalog record
| CREATOR | Matthew Justyn, Cheerly Sutanto, Melisa Intan Barliana, Henhen Heryaman, Anna Meiliana, Irma Melyani Puspitasari |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67026 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |