Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis
Jian Cheng, Yangfeng Huang · 2026
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Description
Jian Cheng and Yangfeng Huang published a 2026 study hunting for key genes in ulcerative colitis, a long-term bowel inflammation, tied to a cell alarm system called the NLRP3 inflammasome. They combined gene activity data from several patient groups with a genetic method that tests cause, aiming to find drug targets and markers.
From 942 changed genes, their filters left three confirmed key genes, all turned down in patients: PPARGC1A, NAAA, and GIPC2. The genes linked to immune cell patterns in the bowel wall. A diabetes drug, rosiglitazone, docked well onto one gene's protein in computer tests, and the bond held steady in motion simulations. Tissue from a mouse model of colitis also showed lower levels of all three genes.
Catalog record
| CREATOR | Jian Cheng, Yangfeng Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87704 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |