Severe Ectopic ACTH–Dependent Cushing Syndrome Due to a Neuroendocrine Tumor of Occult Primary Origin Presenting with Widespread Metastases and Early Vertebral Fractures: A Rare Case Report
Mohammad Nabi Aria, Ahmad Shekaib Rasikh, Ahmad Jawad Tayeb, Mohammad Maroof Aram, Abdul Jalil Hassan, Mohammad Khalid Ferdaws · 2026
Read Severe Ectopic ACTH–Dependent Cushing Syndrome Due to a Neuroendocrine Tumor of Occult Primary Origin Presenting with Widespread Metastases and Early Vertebral Fractures: A Rare Case Report by Mohammad Nabi Aria, Ahmad Shekaib Rasikh, Ahmad Jawad Tayeb, Mohammad Maroof Aram, Abdul Jalil Hassan, Mohammad Khalid Ferdaws (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13265003.txt.
Description
Mohammad Nabi Aria and colleagues present a 2026 case report on severe Cushing syndrome caused by a hidden hormone-making tumor. In this syndrome, excess cortisol from a tumor outside the pituitary gland floods the body. Their patient was a 30-year-old woman with growing leg weakness, body pain, and trouble walking, plus new high blood pressure and diabetes.
Scans found no pituitary tumor but showed spread to lungs and liver and fractures in the spine. A liver sample confirmed a mid-grade neuroendocrine tumor, possibly from the pancreas, though no source tumor could be found. Treatment covered her diabetes and blood pressure, two drugs to lower cortisol, and fracture support, bringing partial improvement. The authors highlight the diagnostic difficulty, above all in low-resource settings, and the need for team care.
Catalog record
| CREATOR | Mohammad Nabi Aria, Ahmad Shekaib Rasikh, Ahmad Jawad Tayeb, Mohammad Maroof Aram, Abdul Jalil Hassan, Mohammad Khalid Ferdaws |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20744 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |