Toll interacting protein (TOLLIP) serum concentration in patients with systemic sclerosis (SSc), with and without interstitial lung disease (ILD)
Niels Schröder, Jitka Andrä, Diana Knuth-Rehr, Silke Leja, Nicolas Hunzelmann, Eda Börner, Kimberly Barbet, Francesco Bonella · 2026
Read Toll interacting protein (TOLLIP) serum concentration in patients with systemic sclerosis (SSc), with and without interstitial lung disease (ILD) by Niels Schröder, Jitka Andrä, Diana Knuth-Rehr, Silke Leja, Nicolas Hunzelmann, Eda Börner, Kimberly Barbet, Francesco Bonella (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13264915.txt.
Description
Niels Schröder and colleagues measure a blood protein called TOLLIP in people with systemic sclerosis, in a 2026 study. Systemic sclerosis can scar the lungs, a complication called interstitial lung disease. Gene variants affecting TOLLIP have been linked to lung scarring in another disease. Whether blood levels mark lung involvement here was unknown.
The cohort held 106 patients, half with lung disease, plus 60 healthy controls. Patients overall had slightly lower TOLLIP than controls. Those with lung disease had higher levels than those without. A set threshold identified lung disease with moderate accuracy. Levels did not differ by the two gene variants tested.
Catalog record
| CREATOR | Niels Schröder, Jitka Andrä, Diana Knuth-Rehr, Silke Leja, Nicolas Hunzelmann, Eda Börner, Kimberly Barbet, Francesco Bonella |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |