USP1-mediated lipophagy-lipogenesis axis drives cholangiocarcinoma progression and immune evasion
Yananlan Chen, Xiao Xu, Shenye Shao, Jiawei Zhang, Ziyang Wang, Changan Chen, Wangjie Jiang, Jiang Chang, Ruixiang Chen, Tao Zhou, Jifei Wang, Shuochen Liu, Yue Yu, Yaodong Zhang, Changxian Li, Xiangcheng Li · 2026
Read USP1-mediated lipophagy-lipogenesis axis drives cholangiocarcinoma progression and immune evasion by Yananlan Chen, Xiao Xu, Shenye Shao, Jiawei Zhang, Ziyang Wang, Changan Chen, Wangjie Jiang, Jiang Chang, Ruixiang Chen, Tao Zhou, Jifei Wang, Shuochen Liu, Yue Yu, Yaodong Zhang, Changxian Li, Xiangcheng Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13264912.txt.
Description
Yananlan Chen and colleagues trace how a protein called USP1 helps bile duct cancer grow and hide from immunity, in a 2026 laboratory study. Cholangiocarcinoma arises in the bile ducts and often resists treatment. Its surroundings show disordered fat metabolism and weak immune attack. The team searched for the main metabolic driver.
Combined chemical and gene analyses found long-chain unsaturated fats enriched in tumour tissue. USP1 was raised in tumours and linked to worse outlook. The protein boosted both fat breakdown for reuse and new fat production. Tumour fats were taken up by nearby immune cells. Tests in humanised mice assessed a combined treatment approach.
Catalog record
| CREATOR | Yananlan Chen, Xiao Xu, Shenye Shao, Jiawei Zhang, Ziyang Wang, Changan Chen, Wangjie Jiang, Jiang Chang, Ruixiang Chen, Tao Zhou, Jifei Wang, Shuochen Liu, Yue Yu, Yaodong Zhang, Changxian Li, Xiangcheng Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 118 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |