Effect of supplemental hydrocortisone during stress in prednisolone-induced adrenal insufficiency: a study protocol for a multicentre, randomised, double-blinded, placebo-controlled clinical trial on health-related quality of life in patients with polymyalgia rheumatica/giant cell arteritis on low-d
Stina Willemoes Borresen, Simon Bøggild Hansen, Hajir Al-Jorani, Randi Tei, Anja Fenger Dreyer, Victor Brun Boesen, Lise Sofie Bislev, Nanna Thurmann Jørgensen, Richard Christian Jensen, Marie Louise Lund Bjergstrøm, Louise Lehmann Christensen, Jelena Skaaning Stankovic Frederiksen, Dorte Glintborg, · 2026
Read Effect of supplemental hydrocortisone during stress in prednisolone-induced adrenal insufficiency: a study protocol for a multicentre, randomised, double-blinded, placebo-controlled clinical trial on health-related quality of life in patients with polymyalgia rheumatica/giant cell arteritis on low-d by Stina Willemoes Borresen, Simon Bøggild Hansen, Hajir Al-Jorani, Randi Tei, Anja Fenger Dreyer, Victor Brun Boesen, Lise Sofie Bislev, Nanna Thurmann Jørgensen, Richard Christian Jensen, Marie Louise Lund Bjergstrøm, Louise Lehmann Christensen, Jelena Skaaning Stankovic Frederiksen, Dorte Glintborg, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13264856.txt.
Description
Stina Willemoes Borresen and a large team of co-authors set out, in a 2026 protocol, a trial on hormone support during illness stress. Long use of the steroid prednisolone can leave the adrenal glands unable to answer stress, which lowers quality of life and risks a crisis. The trial, called RESCUE, enrolls patients with two related inflammatory diseases who take a low daily dose.
Patients whose glands test weak are split at random to get extra hydrocortisone or a dummy pill on mildly stressful sick days, for six months. The goal is 250 patients enrolled and 200 finishing at least three months. Severe stress is treated openly with the hormone for safety. The main question is whether the extra hormone lifts daily quality of life.
Catalog record
| CREATOR | Stina Willemoes Borresen, Simon Bøggild Hansen, Hajir Al-Jorani, Randi Tei, Anja Fenger Dreyer, Victor Brun Boesen, Lise Sofie Bislev, Nanna Thurmann Jørgensen, Richard Christian Jensen, Marie Louise Lund Bjergstrøm, Louise Lehmann Christensen, Jelena Skaaning Stankovic Frederiksen, Dorte Glintborg, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |