Comparative efficacy and acceptability of treatment options for depressive disorders in children and adolescents: protocol of a network meta-analysis
Jing Guo, Zhe Lu, Yuyanan Zhang, Yaoyao Sun, Zhewei Kang, Junyuan Sun, Guorui Zhao, Xiaoyang Feng, Rui Yuan, Yunqing Zhu, Tong Yu, Yang Yang, Huan Chen, Weihua Yue · 2026
Read Comparative efficacy and acceptability of treatment options for depressive disorders in children and adolescents: protocol of a network meta-analysis by Jing Guo, Zhe Lu, Yuyanan Zhang, Yaoyao Sun, Zhewei Kang, Junyuan Sun, Guorui Zhao, Xiaoyang Feng, Rui Yuan, Yunqing Zhu, Tong Yu, Yang Yang, Huan Chen, Weihua Yue (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13264846.txt.
Description
Jing Guo and a large team present a 2026 protocol for a network meta-analysis of treatments for depression in children and young people. Depression in youth is rising, and drugs, talk therapy, and physical treatments all see use, but no single review has compared them all. A network method can rank treatments by mixing direct and side-by-side indirect proof.
The team will gather randomized trials from seven databases, with searches updated to November 2025. Two reviewers will screen studies, pull data, and grade bias risk with a standard tool. The main outcome is change in depression symptoms. Side outcomes include dropout, response, full recovery, and daily functioning. Findings will be shared in peer journals, and the plan is logged in a public registry. No ethics approval is needed for this reuse of past studies.
Catalog record
| CREATOR | Jing Guo, Zhe Lu, Yuyanan Zhang, Yaoyao Sun, Zhewei Kang, Junyuan Sun, Guorui Zhao, Xiaoyang Feng, Rui Yuan, Yunqing Zhu, Tong Yu, Yang Yang, Huan Chen, Weihua Yue |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36396 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |