Anchusa azurea enhances cisplatin efficacy in oral and bone cancers through IL-17 and TNF-α pathway modulation: a metabolomic and network pharmacology approach
Sally A. Fahim, Alaadin E. El-Haddad, Rehab I. Moustafa, Shimaa O. Ali, Marwa Sharaky, Nouran H. El Sherazy, Aliaa A. Elsherbiny, Ashrakat Y. Nabawy, Ahmed A. Elwakil, Heba Alah Esam, Salma Emad, Menatallah Abdelrahman, Mohamad Ayman, Hind A. H. Soliman, Eman M. El-Deeb, Amr M. Saadeldeen · 2026
Read Anchusa azurea enhances cisplatin efficacy in oral and bone cancers through IL-17 and TNF-α pathway modulation: a metabolomic and network pharmacology approach by Sally A. Fahim, Alaadin E. El-Haddad, Rehab I. Moustafa, Shimaa O. Ali, Marwa Sharaky, Nouran H. El Sherazy, Aliaa A. Elsherbiny, Ashrakat Y. Nabawy, Ahmed A. Elwakil, Heba Alah Esam, Salma Emad, Menatallah Abdelrahman, Mohamad Ayman, Hind A. H. Soliman, Eman M. El-Deeb, Amr M. Saadeldeen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13264614.txt.
Description
Sally A Fahim and a large team published a 2026 lab study on Anchusa azurea, a plant long used in folk care for joint pain and skin wounds. They tested its extract alongside cisplatin, a strong cancer drug with harsh side effects, on cancer cells grown in dishes. The aim was to see if the plant boosts the drug.
The extract slowed bone and oral cancer cells while sparing normal skin cells, and the pair worked better together than either alone. Treated cells showed lower levels of two inflammation signals and higher levels of proteins that drive cell death. Chemical profiling found 50 plant compounds, led by rosmarinic acid. The authors call for animal tests next.
Catalog record
| CREATOR | Sally A. Fahim, Alaadin E. El-Haddad, Rehab I. Moustafa, Shimaa O. Ali, Marwa Sharaky, Nouran H. El Sherazy, Aliaa A. Elsherbiny, Ashrakat Y. Nabawy, Ahmed A. Elwakil, Heba Alah Esam, Salma Emad, Menatallah Abdelrahman, Mohamad Ayman, Hind A. H. Soliman, Eman M. El-Deeb, Amr M. Saadeldeen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59944 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |