RNF126 mediates fetal growth restriction via ubiquitination-dependent degradation of the MYH9/MYH10 complex
Lilin Lu, Xiaomei Ye, Jiawen Lan, Shuxiu Xu, Manyu Cheng, Chenlin Lv, Jun Zhou, Jing Li · 2026
Read RNF126 mediates fetal growth restriction via ubiquitination-dependent degradation of the MYH9/MYH10 complex by Lilin Lu, Xiaomei Ye, Jiawen Lan, Shuxiu Xu, Manyu Cheng, Chenlin Lv, Jun Zhou, Jing Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13264122.txt.
Description
Lilin Lu and colleagues identify a placental mechanism behind fetal growth restriction in a 2026 study. Babies who grow too slowly before birth face higher risks around delivery and later in life, and clear molecular causes remain few. Comparing placental tissue from affected and normal pregnancies pointed to RNF126, an enzyme that tags proteins for disposal, as a distinguishing regulator.
Mice engineered to lack this gene only in the placenta showed its causal role. Extra RNF126 stressed placental cells and triggered cell death by driving destruction of a structural protein pair, MYH9 and MYH10. One precise tagging site was pinpointed. The findings suggest RNF126 testing could separate true growth restriction from simply small babies, and that blocking it merits exploration.
Catalog record
| CREATOR | Lilin Lu, Xiaomei Ye, Jiawen Lan, Shuxiu Xu, Manyu Cheng, Chenlin Lv, Jun Zhou, Jing Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |