Rewriting microenvironment immunity in glioblastoma
John W. Figg, Catherine T. Flores · 2026
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Description
John W. Figg and Catherine T. Flores review work on changing immune suppression inside glioblastoma tumors in a 2026 article. Glioblastoma is the most common primary brain tumor and remains fatal despite surgery, radiation and chemotherapy. A key obstacle is a population of suppressive immune cells that block T cells, the immune cells that attack tumors, from working well.
The authors describe an adoptive cell therapy platform from their group that combines host conditioning, stem cell transfer and a dendritic cell vaccine. In mouse models the therapy raised survival and reduced suppressive cells inside tumors. New flow cytometry and spatial genomics work examines how that shift happens. The article frames tumor immune makeup as a target that treatment can rewrite.
Catalog record
| CREATOR | John W. Figg, Catherine T. Flores |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |