Rethinking the Siewert classification in the era of precision oncology
Lawrence W. Wu, Ryan H. Moy · 2026
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Description
Lawrence W. Wu and Ryan H. Moy offer a 2026 review that questions an older anatomy-based system for cancers where the esophagus meets the stomach. The Siewert system groups tumors by their center above or below the gastric cardia and has long guided surgical choices. Modern care now also uses systemic drugs, biomarkers, targeted treatments and immunotherapy, which the original system did not reflect.
The review sets Siewert types beside molecular subtypes described by large cancer genome projects, including chromosomal instability and microsatellite instability groups. Evidence from a major cancer center suggests molecular type predicts survival apart from tumor location. Readers see why future classification may need to combine anatomy with tumor biology rather than rely on location alone.
Catalog record
| CREATOR | Lawrence W. Wu, Ryan H. Moy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |