DNAm landscape up to 4 months post SARS-CoV-2 infection: insights from four population-based cohorts

Pamela R Matías-García, Liye Lai, Thomas Delerue, Jochen Ohnmacht, Klaus J Stark, Robert Warmerdam, Alexey Kolodkin, Julia Six-Merker, Nina Mangold, Kathrin Günther, Marc P O’Sullivan, Armin Rauschenberger, Barbara Bohn, Klaus Berger, Julia Fricke, Peter Ahnert, Lude Franke, Rejko Krüger, Olaf Gefeller, Klaus Überla, Iris M Heid, Ralf Wagner, Lifelines Corona Research Initiative, TiKoCo Working Group, CON-VINCE Consortium, NAKO Investigators, Melanie Waldenberger, Annette Peters · 2026

Read DNAm landscape up to 4 months post SARS-CoV-2 infection: insights from four population-based cohorts by Pamela R Matías-García, Liye Lai, Thomas Delerue, Jochen Ohnmacht, Klaus J Stark, Robert Warmerdam, Alexey Kolodkin, Julia Six-Merker, Nina Mangold, Kathrin Günther, Marc P O’Sullivan, Armin Rauschenberger, Barbara Bohn, Klaus Berger, Julia Fricke, Peter Ahnert, Lude Franke, Rejko Krüger, Olaf Gefeller, Klaus Überla, Iris M Heid, Ralf Wagner, Lifelines Corona Research Initiative, TiKoCo Working Group, CON-VINCE Consortium, NAKO Investigators, Melanie Waldenberger, Annette Peters (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13263947.txt.

Description

Pamela R Matías-García and a large team reported in 2026 on DNA methylation, a chemical mark on DNA, after mild SARS-CoV-2 infection. Using data from four large population cohorts, they asked whether marks in blood stay changed for months. The study sits inside the wider ORCHESTRA project.

The team compared 675 cases and matched controls up to four months after infection. They found changes at 16 single sites and 21 regions, and most marks were lower in people who had been ill. Many linked genes help the body fight viruses, and four sites matched changes seen in the first days of illness. The authors call the shifts modest but lasting.

Catalog record

CREATORPamela R Matías-García, Liye Lai, Thomas Delerue, Jochen Ohnmacht, Klaus J Stark, Robert Warmerdam, Alexey Kolodkin, Julia Six-Merker, Nina Mangold, Kathrin Günther, Marc P O’Sullivan, Armin Rauschenberger, Barbara Bohn, Klaus Berger, Julia Fricke, Peter Ahnert, Lude Franke, Rejko Krüger, Olaf Gefeller, Klaus Überla, Iris M Heid, Ralf Wagner, Lifelines Corona Research Initiative, TiKoCo Working Group, CON-VINCE Consortium, NAKO Investigators, Melanie Waldenberger, Annette Peters
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE61650
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13263947

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