Neuroglial P2Y1 receptor signalling differentially contributes to inflammatory neurodegeneration
Charlotte Schubert, Ricardo Lopes Fonseca, Alexandros Hadjilaou, Vanessa Vieira, Karoline Degenhardt, Anna Lena Seemann, Alice Hakimy, Jana K. Sonner, Peter Ludewig, Tim Magnus, Marion Schneider, Christa E. Müller, Daniela Hirnet, Manuel A. Friese · 2026
Read Neuroglial P2Y1 receptor signalling differentially contributes to inflammatory neurodegeneration by Charlotte Schubert, Ricardo Lopes Fonseca, Alexandros Hadjilaou, Vanessa Vieira, Karoline Degenhardt, Anna Lena Seemann, Alice Hakimy, Jana K. Sonner, Peter Ludewig, Tim Magnus, Marion Schneider, Christa E. Müller, Daniela Hirnet, Manuel A. Friese (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13263940.txt.
Description
Charlotte Schubert and co-authors report a 2026 journal article on a receptor that helps drive nerve damage in multiple sclerosis, an autoimmune disease of the brain and spinal cord. The receptor, P2Y1, responds to ATP, the cell's energy currency, spilled outside cells. Using mice with a sclerosis-like illness, the team tracked the receptor in astrocytes, the brain's support cells, and in neurons.
Extracellular ATP rose during acute illness, and astrocyte receptor levels rose with it. Blocking the receptor, or deleting it only in astrocytes, reduced disease severity, astrocyte overgrowth, and neuron loss. Fluid from receptor-bearing astrocytes harmed neurons in dishes. Neuron-side signaling instead fed oxidative stress. The authors name astrocytic P2Y1 a promising drug target.
Catalog record
| CREATOR | Charlotte Schubert, Ricardo Lopes Fonseca, Alexandros Hadjilaou, Vanessa Vieira, Karoline Degenhardt, Anna Lena Seemann, Alice Hakimy, Jana K. Sonner, Peter Ludewig, Tim Magnus, Marion Schneider, Christa E. Müller, Daniela Hirnet, Manuel A. Friese |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67174 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |