Differential expression of ALOX15 and GPX4 in the testicular tissue of men with obstructive and non-obstructive azoospermia: a cross-sectional study
Lucija Romac, Pavle Romac, Jelena Schwenner-Radovniković, Marica Maretić, Damir Sapunar · 2026
Read Differential expression of ALOX15 and GPX4 in the testicular tissue of men with obstructive and non-obstructive azoospermia: a cross-sectional study by Lucija Romac, Pavle Romac, Jelena Schwenner-Radovniković, Marica Maretić, Damir Sapunar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13263816.txt.
Description
Lucija Romac and colleagues measured in 2026 two enzymes tied to an iron-driven cell death pathway in the testes of men producing no sperm. One enzyme, ALOX15, feeds fat oxidation, while GPX4 defends against it. Tissue came from 72 men undergoing sperm extraction, split into blocked-duct cases and production-failure cases of graded severity.
Sperm retrieval succeeded in about sixty-three percent, yielding 14 blocked-duct and 31 production-failure samples for staining. Both enzymes appeared more strongly in the blocked-duct group, where sperm production itself runs normally. Expression faded as production failure deepened from mild to severe. The protective enzyme held up in mild and moderate failure but dropped in severe cases. The authors read the pattern as a shadow of vanishing mature germ cells rather than proof of runaway oxidative damage.
Catalog record
| CREATOR | Lucija Romac, Pavle Romac, Jelena Schwenner-Radovniković, Marica Maretić, Damir Sapunar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |