Challenges for first-line therapy in elderly patients with metastatic non-small cell lung cancer
Thierry Landre, Lorenzo Tommasi, Christos Chouaïd · 2026
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Description
Thierry Landre, Lorenzo Tommasi, and Christos Chouaid, in a 2026 review, ask how best to treat older people with lung cancer that has spread. New drug pairs that pair chemo with immune drugs are now the usual first step for fit patients. Yet the big trials behind them took in mostly younger people in good shape.
Older and frail patients face other health problems, and they may bear side effects less well. The authors look at three trials made just for this group. One trial, in 510 patients aged 70 to 89, found no clear gain in length of life from adding an immune drug. Disease control was better, but side effects were worse. The review uses such results to frame first choices for older patients.
Catalog record
| CREATOR | Thierry Landre, Lorenzo Tommasi, Christos Chouaïd |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |