Bergapten attenuates oxidative stress and neuroinflammation to promote the survival and neuronal differentiation of neural stem/progenitor cells after ischemic insult
Zelong Tang, Yannian Li, Yan Gao, Yiping Wu, Wei Tian · 2026
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Description
Zelong Tang and colleagues test a plant coumarin as a guard for brain stem cells after stroke-like injury. Bergapten, from the furanocoumarin family, already shows signs of fighting oxidative damage and swelling. Their 2026 lab study mimics the hostile zone around a stroke with hydrogen peroxide on mouse cells.
Peroxide flooded neural stem cells with reactive oxygen and drove many to die, while pushing microglia toward their attack mode. Bergapten fought the oxidative stress and calmed the inflammation in their assays. Guarded stem cells lived on better and chose nerve-cell fates more readily under stress. The authors frame the compound as a hope for mending the stroke-damaged brain's own nursery.
Catalog record
| CREATOR | Zelong Tang, Yannian Li, Yan Gao, Yiping Wu, Wei Tian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |