Pathological complete response and postmastectomy radiation therapy after primary systemic therapy: results from the ReSTORE study
Liat Mizrahi, Marianna Valzano, Rinat Bernstein Molho, Carlotta Becherini, Luca Visani, Viola Salvestrini, Chiara Mattioli, Andrea Rampini, Lorenzo Livi, Ben Boursi, Icro Meattini, Orit Kaidar-Person · 2026
Read Pathological complete response and postmastectomy radiation therapy after primary systemic therapy: results from the ReSTORE study by Liat Mizrahi, Marianna Valzano, Rinat Bernstein Molho, Carlotta Becherini, Luca Visani, Viola Salvestrini, Chiara Mattioli, Andrea Rampini, Lorenzo Livi, Ben Boursi, Icro Meattini, Orit Kaidar-Person (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13263668.txt.
Description
Liat Mizrahi and colleagues ask whether a complete response to pre-surgery therapy lets breast cancer patients skip chest wall radiation. The multicenter ReSTORE study follows two hundred fifty-six women treated with drug therapy, then mastectomy with reconstruction. Their 2026 analysis weighs response, nodal status, and radiation together.
Patients whose tumors vanished completely enjoyed clearly better disease-free survival. Positive nodes at diagnosis, though, predicted local relapse strongly. Radiation was linked to fewer local recurrences, but the difference was not statistically firm. Among irradiated patients, complete responders fared best of all. Skipping radiation on response alone is not supported, they conclude.
Catalog record
| CREATOR | Liat Mizrahi, Marianna Valzano, Rinat Bernstein Molho, Carlotta Becherini, Luca Visani, Viola Salvestrini, Chiara Mattioli, Andrea Rampini, Lorenzo Livi, Ben Boursi, Icro Meattini, Orit Kaidar-Person |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |