Evaluating the substitutability of fruit versus menthol and tobacco-flavored e-cigarettes on combustible cigarette cessation: Randomized clinical trial protocol
Olivia Klapec, Andrew A Strasser, E Paul Wileyto, Janet Audrain-McGovern · 2026
Read Evaluating the substitutability of fruit versus menthol and tobacco-flavored e-cigarettes on combustible cigarette cessation: Randomized clinical trial protocol by Olivia Klapec, Andrew A Strasser, E Paul Wileyto, Janet Audrain-McGovern (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13263626.txt.
Description
Olivia Klapec and colleagues lay out a randomized trial to settle whether fruit-flavored e-cigarettes help smokers quit better than the flavors regulators allow. Pod fruit flavors were restricted despite hints they aid switching. Their 2026 protocol recruits daily smokers with repeated failed quit attempts who want to switch.
Participants draw fruit, menthol, or tobacco pods for six weeks, plus a structured switching plan. Lab sessions first measure how rewarding each flavor feels against real cigarettes. Daily cigarette counts through the switch and at twenty-six weeks form the main outcome, verified by breath carbon monoxide. The design also tests whether reward explains any flavor advantage.
Catalog record
| CREATOR | Olivia Klapec, Andrew A Strasser, E Paul Wileyto, Janet Audrain-McGovern |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |