Immunomodulatory Effects of Wheat Peptides and a Novel Octapeptide (GFNDLGKR) in Immunosuppressed Zebrafish and Mouse Models
Fei Shen, Jiahao Chen, Lina Xiong, Yujie Zhou, Yunjing Han, Juan Du, Wei Zhang, Fengqin Feng, Jiaojiao Zhang, Guanghua He, Lida Wang · 2026
Read Immunomodulatory Effects of Wheat Peptides and a Novel Octapeptide (GFNDLGKR) in Immunosuppressed Zebrafish and Mouse Models by Fei Shen, Jiahao Chen, Lina Xiong, Yujie Zhou, Yunjing Han, Juan Du, Wei Zhang, Fengqin Feng, Jiaojiao Zhang, Guanghua He, Lida Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13263540.txt.
Description
Fei Shen and co-authors report a 2026 journal article on wheat peptides, short protein fragments, as immune boosters in weakened animals. Immune suppression raises infection risk. The team tested wheat peptides in zebrafish made immunosuppressed by an antibiotic and in mice suppressed by a chemotherapy drug.
In zebrafish the peptides restored counts of macrophages, the immune system's scavenger cells, and raised neutrophil activity and interferon-gamma, a key defense signal, by roughly thirty to forty percent. Mice showed healthier spleen and thymus sizes and higher antibody levels. Chemical analysis singled out one eight-part fragment, GFNDLGKR, which bound its target best in computer docking and boosted zebrafish immune measures by about sixty percent.
Catalog record
| CREATOR | Fei Shen, Jiahao Chen, Lina Xiong, Yujie Zhou, Yunjing Han, Juan Du, Wei Zhang, Fengqin Feng, Jiaojiao Zhang, Guanghua He, Lida Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42395 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |