Anti‐Ma2 Antibody‐Associated Paraneoplastic Cerebellar Degeneration Mimicking the Cerebellar Ataxic Subtype of Hashimoto’s Encephalopathy: A Case Report
Masato Okitsu, Shintaro Nojiri, Tomoya Kawazoe, Akihito Hao, Kazushi Takahashi · 2026
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Description
Masato Okitsu and co-authors present a 2026 case report of a 55-year-old woman with worsening balance and coordination problems. She had slurred speech and failing handwriting and gait. A history of Hashimoto's thyroiditis, an autoimmune thyroid disease, plus very high thyroid antibody levels first suggested a related brain disorder called Hashimoto's encephalopathy.
Steroid treatment helped little, which argued against that diagnosis. Further testing found anti-Ma2 antibodies, pointing to a paraneoplastic disorder, where the immune response to a hidden tumor attacks the cerebellum. Treatment with immunoglobulin, pooled donor antibodies, improved her symptoms and scans. No cancer was found, but the authors stress that patients like her need continued cancer surveillance.
Catalog record
| CREATOR | Masato Okitsu, Shintaro Nojiri, Tomoya Kawazoe, Akihito Hao, Kazushi Takahashi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14194 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |