Targeted next-generation sequencing reveals pathogen spectrum, drug resistance characteristics, and clinical determinants in children with community-acquired pneumonia
Pei-Pei Cai, Dong Shen, Ru-Hong Yan, Jiang-Tao Wen, Chang-Song Zhang, Bei Chen · 2026
Read Targeted next-generation sequencing reveals pathogen spectrum, drug resistance characteristics, and clinical determinants in children with community-acquired pneumonia by Pei-Pei Cai, Dong Shen, Ru-Hong Yan, Jiang-Tao Wen, Chang-Song Zhang, Bei Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13263466.txt.
Description
Pei-Pei Cai and colleagues applied in 2026 targeted gene sequencing to children with community-acquired pneumonia and other acute airway infections. Standard antibody tests for Mycoplasma pneumoniae can mislead, so the team compared sequencing of throat swabs against the rapid IgM test and clinical records. Children ranged from three months to thirteen years old.
Viruses were the most common finds, appearing in about seven in ten cases. Mycoplasma turned up in about a third of children, and most of those carried a macrolide resistance gene, always the same single mutation. Over half of antibody-positive children tested negative by sequencing, a warning against trusting the antibody result alone. Resistance genes did not predict worse illness, while lobar pneumonia and Mycoplasma presence flagged progression risk. Tetracycline brought no clear outcome gain in their data.
Catalog record
| CREATOR | Pei-Pei Cai, Dong Shen, Ru-Hong Yan, Jiang-Tao Wen, Chang-Song Zhang, Bei Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |