The predictive value of the ratio of multi-dimensional inflammatory biomarkers in pediatric diseases from the perspective of pro-inflammatory/anti-inflammatory balance: a systematic review
Xuepeng Chen, Bo Ding, Zixuan Shen, Weicheng Han, Yi Li, Yilu Xie, Kaijing Wang, Yazhou Wang · 2026
Read The predictive value of the ratio of multi-dimensional inflammatory biomarkers in pediatric diseases from the perspective of pro-inflammatory/anti-inflammatory balance: a systematic review by Xuepeng Chen, Bo Ding, Zixuan Shen, Weicheng Han, Yi Li, Yilu Xie, Kaijing Wang, Yazhou Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13263423.txt.
Description
Xuepeng Chen and colleagues reviewed in 2026 ratios that pair pro-inflammatory and anti-inflammatory markers to predict disease in children. Single markers cannot capture the immune system's overall balance. Their systematic review gathered thirty-two studies of children with inflammatory conditions.
The ratios split into two classes. Cytokine ratios, built from paired signaling proteins, reflect immune balance with precision but need special tests. Ratios from routine blood counts and proteins are cheaper and faster, suiting quick screening. Across sepsis, Kawasaki disease, juvenile arthritis, and the post-COVID multisystem syndrome, ratios beat single markers at forecasting severity and outcome. The authors propose using both classes together: routine ratios for early sorting, cytokine ratios for finer immune typing and targeted therapy choices.
Catalog record
| CREATOR | Xuepeng Chen, Bo Ding, Zixuan Shen, Weicheng Han, Yi Li, Yilu Xie, Kaijing Wang, Yazhou Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |