Reduction in Seizure Generalization Associated With Long‐Term Low‐Dose Immunomodulatory Therapy Using Prednisolone and Methotrexate in Rett Syndrome: A Case Report
Naylya Djumaeva, Baisakhi Banerjee · 2026
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Description
Naylya Djumaeva and Baisakhi Banerjee present a 2026 case report on seizure change in a girl with Rett syndrome, a severe developmental disorder usually caused by variants in the MECP2 gene. The girl developed normally at first, then around age two lost speech, began repetitive hand movements, and started having seizures.
Her seizures resisted standard anti-seizure medicines. Doctors added long-term low-dose prednisolone and methotrexate, two drugs that calm the immune system, suspecting that brain inflammation helps seizures spread. Over follow-up, her whole-body seizures became less frequent and were replaced by brief partial seizures. The authors caution that one case cannot prove cause, but the shift supports testing immune-based treatment further.
Catalog record
| CREATOR | Naylya Djumaeva, Baisakhi Banerjee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31194 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |