Extracellular flux analyses indicate low ATP yield and require refinement for accurate determination of maximal oxygen consumption rate
Celine Ransy, Mathieu Boissan, Noureddine Hammad, Abdelouhab Bouaboud, Tarik Issad, Maud De Dieuleveult, Benoit Miotto, Manuela Ye, Eric Pasmant, Frédéric Bouillaud · 2026
Read Extracellular flux analyses indicate low ATP yield and require refinement for accurate determination of maximal oxygen consumption rate by Celine Ransy, Mathieu Boissan, Noureddine Hammad, Abdelouhab Bouaboud, Tarik Issad, Maud De Dieuleveult, Benoit Miotto, Manuela Ye, Eric Pasmant, Frédéric Bouillaud (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13263325.txt.
Description
Celine Ransy and co-authors report a 2026 journal article questioning a standard lab test of how cells make energy. The Seahorse analyzer measures oxygen use by cells, and its Mito Stress Test estimates the maximum rate, called maximal OCR. That figure is read as the cells' spare breathing capacity.
Reviewing 97 recent papers covering 530 tests, the authors found that in about seventeen percent maximal oxygen use came out lower than resting use, an impossible result. They propose a Cell Stimulation Test that drives breathing up directly across a wide dose range. Using both tests on one plate improved accuracy, and they estimate about half of resting oxygen use is not tied to energy production.
Catalog record
| CREATOR | Celine Ransy, Mathieu Boissan, Noureddine Hammad, Abdelouhab Bouaboud, Tarik Issad, Maud De Dieuleveult, Benoit Miotto, Manuela Ye, Eric Pasmant, Frédéric Bouillaud |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71083 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |