Posttraumatic Stress Disorder (PTSD) NAD/Sirtuin Deficiency and SARM1-Mediated Synaptic Vulnerability: Evidence for Accelerated Brain Aging Subtypes
Ngo Cheung · 2026
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Description
Ngo Cheung links post traumatic stress disorder with signs of faster brain aging at the gene level, in a solo study from 2026. Anxiety and stress disorders often come with marks of early aging in the body. Yet the pathways that join inherited risk to damage at nerve links and circuits were not clear.
Cheung ran a gene set study that ties gene activity in the brain to large genetic studies of anxiety and the stress disorder. The scan found 185 strong enrichments, with shared themes in cell aging, chromosome end care, and cell power units. The stress disorder alone showed a dip in pathways tied to a key cell fuel and its partner proteins. The work frames subtypes of the disorder marked by weak synapses and faster brain aging.
Catalog record
| CREATOR | Ngo Cheung |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |