Evolution of phenocopying in a dynamical model of developmental trajectories
Yuuki Matsushita, Archishman Raju, Lun Hu, Lun Hu, Lun Hu, Lun Hu, Lun Hu · 2026
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Description
Yuuki Matsushita and co-authors evolve virtual growth in a computer to explain a classic life-science puzzle. Phenocopies occur when outside shocks produce the same flawed outcome as a known mutation. Their 2026 study builds an abstract model of gene switches and evolves it to follow one growth path.
Evolved paths resisted small nudges, as real embryos do, yet big shocks landed them on mutant-like outcomes. Paths built at random showed toughness without that pattern. Evolution, they conclude, sculpts the map where canalization and phenocopying coexist. The result gives theorists a concrete mechanism for an effect noticed nearly a century ago.
Catalog record
| CREATOR | Yuuki Matsushita, Archishman Raju, Lun Hu, Lun Hu, Lun Hu, Lun Hu, Lun Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |