RNA Polymerase III subunit Polr3a is required for craniofacial cartilage and bone development in zebrafish
Bailey T. Lubash, Roxana Gutierrez, Nicole A. Hansen, Kade Fink, Colette A. Hopkins, Lauren B. Sands, Jessica C. Nelson, Kristin E. N. Watt · 2026
Read RNA Polymerase III subunit Polr3a is required for craniofacial cartilage and bone development in zebrafish by Bailey T. Lubash, Roxana Gutierrez, Nicole A. Hansen, Kade Fink, Colette A. Hopkins, Lauren B. Sands, Jessica C. Nelson, Kristin E. N. Watt (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13262943.txt.
Description
Bailey Lubash and colleagues use zebrafish to learn why a ribosome-making gene misshapes the face. Variants in Pol III subunits cause human craniofacial differences, though the machinery works in every cell. Their 2026 study examines fish missing the polr3a subunit.
Mutant fish grew stunted facial cartilage and bone from neural crest cells. Surprisingly, those precursor cells multiplied and survived normally early on; death spread through the head only later. Transfer RNA output and ribosome production sagged in step. A tumor suppressor gene switched on, but blocking it alone could not rescue the face. Extra, still-hidden factors must support the growing skull.
Catalog record
| CREATOR | Bailey T. Lubash, Roxana Gutierrez, Nicole A. Hansen, Kade Fink, Colette A. Hopkins, Lauren B. Sands, Jessica C. Nelson, Kristin E. N. Watt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |