HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition
August Myers, Monika Chandravanshi, Leanne S. Whitmore, Brendan F. Kohrn, Amina Negash, Dung N. Nguyen, Pooja Ralli-Jain, Kendra Cruickshank, Amit A. Upadhyay, Tysheena Charles, Christopher T. Edwards, Eric Hunter, Rama R. Amara, Marek K. Korzeniowski, Ling Niu, Edwin Pozharski, William D. Tolbert, · 2026
Read HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition by August Myers, Monika Chandravanshi, Leanne S. Whitmore, Brendan F. Kohrn, Amina Negash, Dung N. Nguyen, Pooja Ralli-Jain, Kendra Cruickshank, Amit A. Upadhyay, Tysheena Charles, Christopher T. Edwards, Eric Hunter, Rama R. Amara, Marek K. Korzeniowski, Ling Niu, Edwin Pozharski, William D. Tolbert, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13262937.txt.
Description
August Myers and colleagues follow one vaccinated monkey's B cells as they learn to neutralize an HIV vaccine construct. The BG505 SOSIP trimer mimics the virus's envelope spike, and protection in earlier work tracked with antibodies against a glycan hole. Their 2026 study sequences over four thousand seven hundred targeted B cells over time.
Three expanded families produced the neutralizing antibodies, all aiming at the same glycan hole. Structures show each family grabbing the hole differently, one even shoving a sugar aside to reach the CD4 docking loop. Some relatives bound the spot without neutralizing. Repeated vaccination drove the expansion and sharpening behind the strong serum response.
Catalog record
| CREATOR | August Myers, Monika Chandravanshi, Leanne S. Whitmore, Brendan F. Kohrn, Amina Negash, Dung N. Nguyen, Pooja Ralli-Jain, Kendra Cruickshank, Amit A. Upadhyay, Tysheena Charles, Christopher T. Edwards, Eric Hunter, Rama R. Amara, Marek K. Korzeniowski, Ling Niu, Edwin Pozharski, William D. Tolbert, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 105 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |