Clinical Spectrum of Anti-SEZ6L2 Syndrome
Juri Luis Habicht, Guido Cammá, Katharina Wurdack, Bianca Teegen, Harald Prüss, Carsten Finke · 2026
Read Clinical Spectrum of Anti-SEZ6L2 Syndrome by Juri Luis Habicht, Guido Cammá, Katharina Wurdack, Bianca Teegen, Harald Prüss, Carsten Finke (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13262669.txt.
Description
Juri Luis Habicht and colleagues map a rare immune syndrome attacking the cerebellum, the brain region that coordinates movement, in a 2026 journal article. Antibodies against a protein called SEZ6L2 cause the illness, but reports were scattered. The team studied one patient in depth and reviewed all published cases to build a fuller picture.
Their patient, a 45-year-old man, developed severe balance and coordination loss plus thinking, mood, and Parkinson-like features, and improved only slightly despite immune treatment. Brain scans showed his cerebellum shrinking over time. Across 22 cases in total, all had cerebellar signs, 64 percent had thinking symptoms, and 86 percent showed cerebellar shrinkage. Many kept major disability at follow-up.
Catalog record
| CREATOR | Juri Luis Habicht, Guido Cammá, Katharina Wurdack, Bianca Teegen, Harald Prüss, Carsten Finke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29825 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |