Essential Tremor and Digital Biomarkers: A Scoping Review Using the TRACE Framework to Map Readiness for Clinical Trials and Routine Practice
David Ledingham, Antonella Macerollo, Nicola Pavese · 2026
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Description
David Ledingham and colleagues grade how ready digital tremor measures are for real clinical use. Essential tremor is the commonest movement disorder, yet trials still lean on shaky rating scales. Their 2026 scoping review proposes a five-tier readiness ladder, TRACE, and scores one hundred sixty-five studies against it.
Wearable motion sensors dominated the literature, trailed by digitized handwriting and camera methods. Almost every study stalled at the second tier, supervised clinical validity. Only one wrist-worn platform reached trial readiness, and none reached economic readiness. Home testing and patient-anchored change thresholds are the missing rungs, they conclude.
Catalog record
| CREATOR | David Ledingham, Antonella Macerollo, Nicola Pavese |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |