LPAR4 mediates resistance to interferon-induced stress in soft tissue sarcoma
Jin-Fen Xiao, Emily Y. Ko, Ashley Smith, Roberta Piras, Annaliese Fowler, Kristin Ishaya, Longqiang Wang, Bin Wang, Adriana Paulucci-Holthauzen, Sharon M. Landers, Angela D. Bhalla, Keila E. Torres, Diana Shamsutdinova, Khalida M. Wani, Alexander J. Lazar, Emily Z. Keung, Neeta Somaiah, Elise F. Nassif Haddad, Jlenia Guarnerio · 2026
Read LPAR4 mediates resistance to interferon-induced stress in soft tissue sarcoma by Jin-Fen Xiao, Emily Y. Ko, Ashley Smith, Roberta Piras, Annaliese Fowler, Kristin Ishaya, Longqiang Wang, Bin Wang, Adriana Paulucci-Holthauzen, Sharon M. Landers, Angela D. Bhalla, Keila E. Torres, Diana Shamsutdinova, Khalida M. Wani, Alexander J. Lazar, Emily Z. Keung, Neeta Somaiah, Elise F. Nassif Haddad, Jlenia Guarnerio (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13262608.txt.
Description
Jin-Fen Xiao and colleagues study how soft tissue sarcoma, an aggressive cancer of fat, muscle, and similar tissues, resists immune attack in a 2026 journal article. A drug called abemaciclib made sarcoma cells act as if virus-infected, switching on interferon, a defense signal. That response slowed tumors but also switched on a survival pathway.
The team identified a receptor called LPAR4 as the key brake on this defense stress. LPAR4 dulled interferon signaling, lowered cell stress, and helped tumor cells survive treatment. Silencing LPAR4 in lab work raised interferon responses and harmful oxygen byproducts, and pushed cells toward death. Tumors then grew more slowly. The authors propose LPAR4 as a drug target to pair with this approach.
Catalog record
| CREATOR | Jin-Fen Xiao, Emily Y. Ko, Ashley Smith, Roberta Piras, Annaliese Fowler, Kristin Ishaya, Longqiang Wang, Bin Wang, Adriana Paulucci-Holthauzen, Sharon M. Landers, Angela D. Bhalla, Keila E. Torres, Diana Shamsutdinova, Khalida M. Wani, Alexander J. Lazar, Emily Z. Keung, Neeta Somaiah, Elise F. Nassif Haddad, Jlenia Guarnerio |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65335 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |