Nicotinamide metabolism-related signature and lncRNA regulatory network in kidney renal clear cell carcinoma
Pei Dong, Lincong Zhao, Peiyao Shi, Ming Ma, Beixuan Huang, Zhenda Wang, Shaowei Zhang, Huan Liu · 2026
Read Nicotinamide metabolism-related signature and lncRNA regulatory network in kidney renal clear cell carcinoma by Pei Dong, Lincong Zhao, Peiyao Shi, Ming Ma, Beixuan Huang, Zhenda Wang, Shaowei Zhang, Huan Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13262547.txt.
Description
Pei Dong and colleagues build a prognosis score for the commonest kidney cancer from genes of vitamin metabolism. Nicotinamide processing shapes tumor behavior in several cancers but was unmapped in clear cell kidney cancer. Their 2026 analysis mines over five hundred tumor profiles from a public atlas.
The resulting signature sorted patients into risk groups with clearly different survival. It predicted one, three, and five-year outcomes respectably, and held up in an independent European dataset. Immune landscapes differed between the risk groups, as did checkpoint gene patterns. A companion network of small and long RNAs suggests fresh drug targets behind the score.
Catalog record
| CREATOR | Pei Dong, Lincong Zhao, Peiyao Shi, Ming Ma, Beixuan Huang, Zhenda Wang, Shaowei Zhang, Huan Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |