Proximal tubule reabsorptive dysfunction and risk of cardiovascular death among community-living adults: the HUNT-3 cohort
Jesse C Ikeme, Ronit Katz, Marius A Øvrehus, Knut Asbjørn R Langlo, Michelle M Estrella, Michael G Shlipak, Joachim H Ix, Stein I Hallan, Karolina Szummer · 2026
Read Proximal tubule reabsorptive dysfunction and risk of cardiovascular death among community-living adults: the HUNT-3 cohort by Jesse C Ikeme, Ronit Katz, Marius A Øvrehus, Knut Asbjørn R Langlo, Michelle M Estrella, Michael G Shlipak, Joachim H Ix, Stein I Hallan, Karolina Szummer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13262532.txt.
Description
Jesse Ikeme and co-authors linked a kidney tubule problem to heart-related death in a Norwegian cohort, in a 2026 study. The tubules normally reclaim useful proteins from urine. Two urine markers signal when that reclaiming fails. Past links to heart disease came mostly from people who already had kidney disease. This study tested the general population.
A random sample of just over twelve hundred adults was joined with all heart-related deaths in the cohort. Follow-up ran a median of thirteen years. Higher levels of either marker went with higher risk of heart-related death. The links held after adjusting for standard kidney measures. Risk rose step by step across marker levels. No subgroup behaved differently in their checks. The authors argue tubule health adds information beyond the usual kidney tests.
Catalog record
| CREATOR | Jesse C Ikeme, Ronit Katz, Marius A Øvrehus, Knut Asbjørn R Langlo, Michelle M Estrella, Michael G Shlipak, Joachim H Ix, Stein I Hallan, Karolina Szummer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |