In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis
Julika E Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep, Maria Arélin, Konrad Platzer, Torsten Schulz, Andreas Merkenschlager, Wieland Kiess, Steffi Mayer, Rami Abou Jamra, Diana Le Duc, Antje Garten, Anna S Kirstein · 2026
Read In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis by Julika E Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep, Maria Arélin, Konrad Platzer, Torsten Schulz, Andreas Merkenschlager, Wieland Kiess, Steffi Mayer, Rami Abou Jamra, Diana Le Duc, Antje Garten, Anna S Kirstein (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13262494.txt.
Description
Julika Friedrich and co-authors studied a child's fatty tumor in 2026 for clues about a rare genetic disorder. The disorder causes growths in many organs when one of two guard genes fails, yet fatty growths away from the kidney are rarely reported in it.
The child carried one faulty copy of the guard gene and developed a fatty tumor on the buttock that returned after surgery. In the tumor, the second copy was lost too, which switched on a growth pathway. Silencing the gene in fat precursor cells in the lab raised their growth, backing the link. Drugs that block that pathway slowed the faulty cells, a possible route for patients with repeated growths.
Catalog record
| CREATOR | Julika E Friedrich, Julia Hentschel, Sandy Richter, Henriette Kiep, Maria Arélin, Konrad Platzer, Torsten Schulz, Andreas Merkenschlager, Wieland Kiess, Steffi Mayer, Rami Abou Jamra, Diana Le Duc, Antje Garten, Anna S Kirstein |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |