Liver sinusoidal endothelial cell fenestrations in metabolic liver disease: from molecular mechanisms to therapeutic perspectives
Akram S. Al-Mughalles, Junhu Ma, Hong Ma, Cuiyu Zhang, Huangjin Xiao, Xiaoyuan Ma, Qian Zhang, Chenggang Jia, Hua Han, Bi-sen Ding, Shuya Zhang · 2026
Read Liver sinusoidal endothelial cell fenestrations in metabolic liver disease: from molecular mechanisms to therapeutic perspectives by Akram S. Al-Mughalles, Junhu Ma, Hong Ma, Cuiyu Zhang, Huangjin Xiao, Xiaoyuan Ma, Qian Zhang, Chenggang Jia, Hua Han, Bi-sen Ding, Shuya Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13262446.txt.
Description
Akram S Al-Mughalles and co-authors review tiny pores in liver blood vessel cells in a 2026 journal article. The cells line the liver's small blood channels and carry openings called fenestrations that let fats and other materials pass. In fatty liver disease linked to metabolism, these pores are lost early, a change called capillarization.
Loss of the pores upsets the balance of signals that keep them open, the review argues, and drives disease toward its inflamed, more severe form. The authors map the signal web that controls the pores and weigh treatments meant to restore them. They propose combined drug approaches and cell-specific markers to guide care that is matched to each patient.
Catalog record
| CREATOR | Akram S. Al-Mughalles, Junhu Ma, Hong Ma, Cuiyu Zhang, Huangjin Xiao, Xiaoyuan Ma, Qian Zhang, Chenggang Jia, Hua Han, Bi-sen Ding, Shuya Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72267 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |