Melatonin and cerium oxide nanoparticles additively mitigate capecitabine-induced hepatotoxicity via targeting oxidative stress, apoptosis, and ERK signaling
Khalid M. Mohany, Heba M. Elkady, Nashwa Hamad, Sahar E.M. El-Deek · 2026
Read Melatonin and cerium oxide nanoparticles additively mitigate capecitabine-induced hepatotoxicity via targeting oxidative stress, apoptosis, and ERK signaling by Khalid M. Mohany, Heba M. Elkady, Nashwa Hamad, Sahar E.M. El-Deek (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13262367.txt.
Description
Khalid M Mohany and co-authors test two protective agents against liver harm from a cancer drug in a 2026 journal article. The drug is capecitabine, a pill that turns into a cell-killing agent in the body and can injure the liver. The agents are melatonin, a natural hormone, and cerium oxide nanoparticles, tiny mineral particles.
Fifty male rats were split into five groups, including drug-only and combined-treatment groups, over six weeks. The cancer drug raised liver enzymes, lowered natural defenses, and raised cell-death markers. Each protective agent eased these changes on its own. Together they did best, bringing most measures close to normal and keeping liver tissue close to its normal structure.
Catalog record
| CREATOR | Khalid M. Mohany, Heba M. Elkady, Nashwa Hamad, Sahar E.M. El-Deek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60362 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |