Engineering primary metabolism for sustainable production of isoprene in Synechocystis sp. PCC 6803
Paul Bolay, Kim N Janssen, Stefan Timm, Martin Hagemann, Pia Lindberg · 2026
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Description
Paul Bolay and colleagues rewire a photosynthetic bacterium to exhale more isoprene, a building block for rubber and fuels. The cyanobacterium Synechocystis can turn carbon dioxide directly into the gas, but too slowly for industry. Their 2026 engineering stacks three changes onto a carbon-regulator deletion strain.
They shut off the cell's storage polymer production and multiplied copies of the isoprene-making enzyme. Output climbed to the study's best rate, and productivity held even when nitrogen feed fluctuated. Nitrogen is the costliest, dirtiest input in cyanobacterial growth media, so using it better matters. Their strategy should generalize to other solar-made chemicals.
Catalog record
| CREATOR | Paul Bolay, Kim N Janssen, Stefan Timm, Martin Hagemann, Pia Lindberg |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |