Segmental strain in chronic ischemic cardiomyopathy: clarifying the role of multiple-comparison adjustment and the clinical interpretation of limits of agreement
Maajid Mohi Ud Din Malik, Rajesh Prasad Jayaswal · 2026
Read Segmental strain in chronic ischemic cardiomyopathy: clarifying the role of multiple-comparison adjustment and the clinical interpretation of limits of agreement by Maajid Mohi Ud Din Malik, Rajesh Prasad Jayaswal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13262300.txt.
Description
Maajid Mohi Ud Din Malik and Rajesh Prasad Jayaswal write a letter refining a study that compared two imaging methods for measuring heart muscle shortening in patients with chronic artery disease. The original study found the two methods agree well overall but warned they cannot be swapped for tracking one patient. Malik and Jayaswal support that caution and extend two statistical points.
First, the study's seventeen segment-by-segment comparisons were reported without adjusting for multiple testing. Rechecking against the stricter threshold leaves eleven of seventeen differences standing. Second, they clarify how the limits of agreement between the methods should be read clinically. The letter is a model of post-publication review.
Catalog record
| CREATOR | Maajid Mohi Ud Din Malik, Rajesh Prasad Jayaswal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |