Tbx1 heterozygosity in the oligodendrocyte lineage shifts myelinated axon composition in the mouse fimbria without behavioral impairments
Anne Marie Wells, Takaki Tanifuji, Takeshi Takano, Arumu Endo, Gina Kang, Marisa Esparza, Qian Shi, Manzoor A. Bhat, Noboru Hiroi · 2026
Read Tbx1 heterozygosity in the oligodendrocyte lineage shifts myelinated axon composition in the mouse fimbria without behavioral impairments by Anne Marie Wells, Takaki Tanifuji, Takeshi Takano, Arumu Endo, Gina Kang, Marisa Esparza, Qian Shi, Manzoor A. Bhat, Noboru Hiroi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13262079.txt.
Description
Anne Marie Wells and co-authors study a gene called Tbx1 in a 2026 mouse study of brain wiring. The gene sits in a stretch of DNA tied to a known deletion syndrome. Mice with only one working copy of the gene show changed nerve fibers and changed acts. But which cells drive those shifts was unclear. The team cut the gene's dose only in cells that make myelin, the fatty coat on nerve fibers.
Young mice with the change showed a shift in fiber mix in a brain band called the fimbria. One maze effect showed at one month of age and faded by two months. Other tests, from pup calls to social acts, showed no clear change. Lab work also showed the gene acts in both young and mature myelin cells.
Catalog record
| CREATOR | Anne Marie Wells, Takaki Tanifuji, Takeshi Takano, Arumu Endo, Gina Kang, Marisa Esparza, Qian Shi, Manzoor A. Bhat, Noboru Hiroi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |