Not so benign: Life-threatening hematuria from renal papillary necrosis in sickle cell trait
Katharine Hodgen, Parth Joshi, Megan Ngai, Jeffrey Schiff · 2026
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Description
Katharine Hodgen and co-authors recounted in 2026 a dangerous case of kidney bleeding in a young woman with sickle cell trait. The trait is usually called harmless, yet it can injure the kidney's inner tips, a lesion called renal papillary necrosis. Their patient, aged twenty-eight, also carried beta thalassemia.
She bled into her urine again and again, needing transfusion after transfusion despite scans, scope checks, and standard care. A ureteroscope view finally matched papillary necrosis as the source. In all she received twenty-one units of packed red blood cells during intensive team care. The bleeding stopped after oral epsilon-aminocaproic acid, a drug that preserves blood clots. The authors warn that trait-related bleeding can turn life-threatening, and they support clot-preserving drugs as a salvage option when gentler care fails.
Catalog record
| CREATOR | Katharine Hodgen, Parth Joshi, Megan Ngai, Jeffrey Schiff |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |