Ticagrelor-Induced False-Negative Serotonin Release Assay in Heparin-Induced Thrombocytopenia With Stent Thrombosis
Yasser Jamil, Rupinder K. Bahniwal, Andrew H. Nguyen, Edward Howard, Farhan Azad, William B. Ershler, Jamie L.W. Kennedy · 2026
Read Ticagrelor-Induced False-Negative Serotonin Release Assay in Heparin-Induced Thrombocytopenia With Stent Thrombosis by Yasser Jamil, Rupinder K. Bahniwal, Andrew H. Nguyen, Edward Howard, Farhan Azad, William B. Ershler, Jamie L.W. Kennedy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13261934.txt.
Description
Yasser Jamil and co-authors report a 2026 case where a common heart drug hid a dangerous diagnosis. A seventy-two-year-old man arrived with a heart attack and received drug-eluting stents plus ticagrelor, a blood thinner. His platelet count then fell, and clots formed in a stent and in a limb, a pattern pointing to heparin-induced thrombocytopenia with thrombosis.
The standard confirming test, the serotonin release assay, came back negative twice. Doctors swapped ticagrelor for prasugrel, and the same test then turned positive. The team reads this as the first drug masking the test result all along. Despite early bivalirudin treatment and support, the man went on to multiorgan failure. The case warns clinicians to suspect drug interference when test results clash with clear clinical signs.
Catalog record
| CREATOR | Yasser Jamil, Rupinder K. Bahniwal, Andrew H. Nguyen, Edward Howard, Farhan Azad, William B. Ershler, Jamie L.W. Kennedy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |